Abstract: To separate co-channel interference inhibition and spurious response inhibition， a hierarchical method is proposed in this paper to optimize the inter-system compatibility of the communication equipment. The multi-objective genetic algorithm is used to restrain co-channel interference， in which the equipment installation locations serve as decisive variables so that the effects of interference reduction mainly depend on adjusting locations of equipment and the antenna directivity. Based on the equipment location optimization， a set of optimization proposals related to specific electromagnetic compatibility indicators is put forward to further suppress potential spurious response and residual co-channel interference. With the presented hierarchical prediction and optimizing， the overall electromagnetic compatibility of the communication equipment has been significantly improved.