Abstract: Seakeeping is not only an important indicator of the overall performance of a ship, it also has a direct impact on the occurrence of motion sickness among ship personnel; as such, a good seakeeping design is the basis for guaranteeing the crew's comfort and work performance. In this paper, a seakeeping calculation program using the theory of the strip method is written to calculate the seakeeping of the DTMB 5415 standard model, and the vertical acceleration response at the bow and the center of gravity in head waves and under different speeds are obtained. Next, the effects on motion sickness of the vertical accelerations of DTMB 5415 corresponding to the destroyer's heaving are analyzed, and the numerical relationship of motion sickness with the destroyer's seakeeping performance is obtained. The results show that the calculated vertical accelerations at the bow and center of gravity are correct, the accuracy of which satisfies the requirements of motion sickness prediction; and the calculated regularities of the motion sickness are reasonable, and can be applied to analyze and predict the incidence of motion sickness on a ship, as well as to improve human factors in the hull form design of destroyers.