Abstract: Due to the wave and hydrodynamic interaction between two ships advancing parallel on the ocean, their six-degrees-of-freedom motions are much more complex during replenishment. The seakeeping performance of two vessels is analyzed with AQWA. On the basis of the RAO functions of the two parallel vessels, spectrum analysis and time-domain analysis were carried out, and the significant amplitudes were obtained using the computed time-history and correlation function method. The significant amplitudes are compared with the results of the spectrum analysis and good agreement is observed. It is found that hydrodynamic interaction between two ships has a great impact on the process of replenishment. Depending on the results of the analysis, dangerous conditions during the replenishment process could be avoided, thereby ensuring the safety of supply work.